A Sequential Adaptive Intervention Strategy Targeting Remission and Functional Recovery in Young People at Ultrahigh Risk of Psychosis: The Staged Treatment in Early Psychosis (STEP) Sequential Multiple Assignment Randomized Trial

PD Mcgorry; C Mei; GP Amminger; HP Yuen; M Kerr; J Spark; N Wallis; A Polari; S Baird; K Buccilli; SJA Dempsey; N Ferguson; M Formica; M Krcmar; AL Quinn; Y Mebrahtu; A Ruslins; R Street; C Wannan; L Dixon; C Carter; R Loewy; TA Niendam; M Shumway; B Nelson

Journal article

A Sequential Adaptive Intervention Strategy Targeting Remission and Functional Recovery in Young People at Ultrahigh Risk of Psychosis: The Staged Treatment in Early Psychosis (STEP) Sequential Multiple Assignment Randomized Trial

PD Mcgorry, C Mei, GP Amminger, HP Yuen, M Kerr, J Spark, N Wallis, A Polari, S Baird, K Buccilli, SJA Dempsey, N Ferguson, M Formica, M Krcmar, AL Quinn, Y Mebrahtu, A Ruslins, R Street, C Wannan, L Dixon Show all

JAMA Psychiatry | Published : 2023

DOI: 10.1001/jamapsychiatry.2023.1947

Abstract

Importance: Clinical trials have not established the optimal type, sequence, and duration of interventions for people at ultrahigh risk of psychosis. Objective: To determine the effectiveness of a sequential and adaptive intervention strategy for individuals at ultrahigh risk of psychosis. Design, Setting, and Participants: The Staged Treatment in Early Psychosis (STEP) sequential multiple assignment randomized trial took place within the clinical program at Orygen, Melbourne, Australia. Individuals aged 12 to 25 years who were seeking treatment and met criteria for ultrahigh risk of psychosis according to the Comprehensive Assessment of At-Risk Mental States were recruited between April 201..

View full abstract

University of Melbourne Researchers

Patrick McGorry Author

Cristina Mei Author

Paul Amminger Author

Hok Yuen Author

Related Projects (3)

LIPID BIOLOGY FOR PREDICTION AND PREVENTION OF PSYCHOTIC DISORDERS AND PERSISTENT DEPRESSION IN YOUNG PEOPLE

My vision for the next 5 years is to establish ω-3PUFAs as a first-line treatment for indicated prevention of psychosis and persistent depre..

CAN WE PREDICT PSYCHOSIS AND CAN IT BE PREVENTED?

It remains unclear what the causes of schizophrenia and other psychotic disorders are and what the most effective interventions are for prev..

TRANSDIAGNOSTIC MODELS OF CLASSIFICATION, INTERVENTION AND NEUROBIOLOGICAL RESEARCH

Early intervention of mental disorders is reliant on accurate diagnosis, effective intervention strategies and appropriate health services. ..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

Research reported in this publication was supported by the National Institute of Mental Health under award number 1U01MH105258-01. Dr McGorry is supported by a National Health and Medical Research Council Senior Principal Research Fellowship (1155508). Dr Nelson is supported by a National Health and Medical Research Council Senior Research Fellowship (1137687) and a University of Melbourne Dame Kate Campbell Fellowship. Dr Amminger was supported by National Health and Medical Research Council Senior Research Fellowship (1080963).